Moving DNA to a different part of the nucleus can change how

first_img Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe Researchers demonstrated that the technique worked by shifting several gene pairs from central locations (above right) to the edge of the nucleus (above left). They also used the technique to move stretches of DNA known as telomeres—the tips of chromosomes implicated in aging. When they moved the telomeres to the inner edge of the nucleus, the cell grew much more slowly, if at all. But when they put telomeres close to cajal bodies, aggregations of proteins and genetic material that process RNA, the cell perked up: It grew faster and divided sooner than usual. Thus, the researchers conclude, the positioning of the telomeres is very important to keeping a cell healthy and productive.Other researchers say they are impressed with the new CRISPR-GO technique. (GO stands for “genome organization.”) That’s because it opens up a whole new way of altering the organization of the genome, which could pave the way toward a better understanding how the nucleus works and possibly lead to finer control over gene activity to slow aging or prevent disease. Click to view the privacy policy. Required fields are indicated by an asterisk (*) Sign up for our daily newsletter Get more great content like this delivered right to you! Country By Elizabeth PennisiOct. 11, 2018 , 11:00 AM Email H. Wang et al., Cell 10.1016 (2018) Though the 3 meters of DNA inside the nuclei of our cells looks like a jumbled pile of spaghetti, the genome is, in fact, pretty well organized. Now, scientists have discovered—using a modified version of the gene-editing tool CRISPR—that the location of DNA, not just the order of its base pairs, can make a critical difference in how certain parts of the genome work.The nucleus is dynamic, with everything—the chromosomes, the nucleolus, and so on—swirling around seemingly randomly. But in the past decade, researchers have realized that DNA on chromosomes inside can reposition itself in specific ways, ways that may alter the activity of the genes being moved. But, until now, they had no good way of proving that hypothesis.Enter CRISPR: Bioengineers have retooled the gene-editing technique to move specific stretches of DNA from one place to another inside the nucleus itself, they report today in Cell. First, they attach the DNA to a protein that, when prompted by the plant hormone abscisic acid, selectively links up with another protein found only in the target location. The second protein then “snags” the attached DNA, holding it fast in the desired spot. Removing the abscisic acid loosens the connection, freeing the DNA. Moving DNA to a different part of the nucleus can change how it workslast_img read more